Episode 154

Does Testosterone Fuel or Protect Against Prostate Cancer? with Dr. Mohit Khera

In this episode of the Dr. Geo Prostate Podcast, Dr. Geo welcomes Dr. Mohit Khera, a globally recognized leader in men’s health, Professor of Urology and Director of the Executive Health Program at Baylor College of Medicine. With over 160 peer-reviewed publications and decades of clinical experience in testosterone therapy, male infertility, and prostate health, Dr. Khera shares cutting-edge insights on testosterone replacement therapy (TRT), including the rise of oral testosterone like Kyzatrex, and the evolving understanding of testosterone’s relationship to prostate cancer.

Whether you’re considering TRT, recovering from prostate cancer, or supporting a loved one’s health journey, this conversation brings clarity to one of men’s most pressing health topics.

What You’ll Learn:

  • The 4 C’s framework to determine the best TRT option:
  • Cost, Compliance, Convenience, Concentration
  • Why oral testosterone (Kyzatrex, Tlando, Jatenzo) is gaining traction—and what makes them different
  • How Kyzatrex may help preserve fertility by reducing gonadotropin suppression
  • What the TRAVERSE trial revealed about TRT and cardiovascular safety
  • Why low testosterone may be linked to more aggressive prostate cancer
  • What the latest science says about BAT (Bipolar Androgen Therapy) for advanced prostate cancer
  • The truth about testosterone’s impact on BPH and urinary symptoms
  • Why total testosterone isn't enough—labs like SHBG, DHT, estradiol, and free testosterone matter

Key Insights:

  • TRT doesn’t cause prostate cancer — and may even have protective effects in some men.
  • Testosterone is the best barometer of male health—predicting cardiovascular risk, mood, bone density, and more.
  • BAT (Bipolar Androgen Therapy) is showing promise in treating advanced prostate cancer in specific scenarios.
  • Avoid unnecessary aromatase inhibitors and DHT blockers unless clinically indicated.


💡 If you're facing prostate cancer surgery, concerned about erectile function, or simply fascinated by medical innovation, this episode is a must-listen.

👉 Learn more about Kyzatrex at KYZATREX.com/testing-kit.

💡 Don’t forget to subscribe, rate, and leave a review! Each review helps us reach more men who want to thrive, not just survive.

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Thank you to our July 2025 Sponsor

KYZATREX is an FDA-approved oral testosterone replacement therapy that helps restore testosterone levels back to normal. It’s not an injection or a messy gel — just a simple twice-daily pill that fits easily into your routine. Find out where you stand. Order a testing kit today at KYZATREX.com/testing-kit. Call your doctor to learn more about KYZATREX. For more information, visit www.kyzatrex.com or call 1-833-949-5040.

👉 Ask your doctor about Kyzatrex or visit KYZATREX.com/testing-kit. [https://bit.ly/4lUgY0j] to learn more.

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Special Offer: As a listener, you can get the ProLon kit for just $148 using this [https://bit.ly/3TVehAx ].

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The Dr. Geo Prostate Podcast Exclusive Membership

We’ll continue bringing you powerful weekly episodes to support your prostate health journey. But if you’re ready to dive deeper, the Exclusive Membership gives you more: curated transcripts, detailed show notes, expert resources, and member-only perks—all designed to help you live better with age. Join HERE [https://drgeo.com/membership]

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📌 Thanks for tuning in to this week’s episode.

Subscribe to The Dr. Geo YouTube Channel for more content like this and learn how to thrive as you age. [https://www.youtube.com/@DrGeoProstatePodcast

You can also listen to this episode and future episodes of The Dr. Geo Prostate Podcast by clicking [http://drgeo.com/]

Support your urological health with Dr. Geo’s supplement lines:

  • XY Wellness – for prostate cancer lifestyle and nutrition - https://bit.ly/3uJPC7Z
  • Mr. Happy – nutraceuticals for prostate health and male vitality https://bit.ly/43YSDiq
  • Or visit the full Dr. Geo Supplement Store for trusted recommendations. - https://bit.ly/3RJMX6O

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DISCLAIMER: This audio is educational and not medical advice. The views expressed are my own and not those of my employer(s) or affiliated organizations. Use of this content is at your own risk. Geovanni Espinosa, N.D., assumes no liability for any direct or indirect consequences, including economic loss, injury, illness, or death.

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About the Podcast

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The Dr. Geo Prostate Podcast
Integrative Approach to Optimum Men's Health

About your host

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Dr. Geo Espinosa

The Dr. Geo Podcast is a show that takes an integrative approach to men's health, prostate, and functional urology to optimize their health and help them live better with age.


Visit https://drgeo.com/ today to learn how to live your healthiest life.